Fig. 7.

Schematic representation of the ‘burst’ model. Two disconnected volumes are generated by the chromatin structure. The inert tracer GFP does diffuse throughout the high chromatin density networked channel (blue) as well as the low chromatin density surroundings, with intermittent bursts of molecules traversing the channel barrier (red arrows). Many possible intranuclear processes may be responsible for the observed GFP behavior. All of them are energy-consuming processes and involve the local dynamic rearrangement of chromatin structure