Fig. 2.

Binding motifs in mouse myopodin CAC67798. This region forms the core region of synaptopodin 2 encoded by exon 4a. Motifs that have only been described in human myopodin are marked with a star. The green domains represent proline-rich stretches. The heavy black bars are PXXP motifs that are putative SH3 interacting domains. The yellow arrows show three independent α-actinin binding regions (Linnemann et al. 2010). The filamin binding domain (Linnemann et al. 2010), shown by the light violet bar contains the main actin binding region (Weins et al. 2001) (dark purple diagonals). The region marked ne has weak nuclear export activity without a classical NES-motif (Van Impe et al. 2003). NLS is the nuclear localization site; the consensus motifs are in dark blue while additional motifs (De Ganck et al. 2005) are in light blue. Binding motifs for 14-3-3 are shown along with the phosphorylation sites S225 and T272, that are targets of protein kinase A and calcium-calmodulin kinase II (Faul et al. 2005, 2007). The PPXY motif may interact with WW-domain containing proteins. Zyx is the Zyxin binding motif discovered in human myopodin (Yu and Luo 2006)