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A folding funnel (energy/enthalpy on y-axis vs. entropy on x-axis) for a protein in buffer (black) showing more rugged walls of the funnel (depicting misfolding and/or heterogeneity) and a wider opening (unfolded state entropy which is related to compaction) as compared to the same protein in crowded conditions, where the folding funnel appears to have smoother sides and a narrower top
