Table 2. Associations between GIST SLUG expression and 7 clinicopathological factors in the SSGXVIII/AIO series.
| Factor | SLUG negative n (%) | SLUG positive n (%) | P |
|---|---|---|---|
|
Age | |||
| Median (range) | 61.5 (26–75) | 60 (22–83) | 0.806 |
|
Gender | |||
| Female | 113 (73.9) | 40 (26.1) | 0.606 |
| Male | 114 (71.3) | 46 (28.8) | |
|
Tumour size—cm | |||
| Median (range) | 9.7 (2.5–35.0) | 9.0 (1.5–30.0) | 0.930 |
|
Location | |||
| Gastric | 127 (75.1) | 42 (24.9) | 0.228 |
| Non-gastric | 98 (69.0) | 44 (31.0) | |
|
Mitotic count | |||
| <2 | 52 (82.5) | 11 (17.5) | 0.245 |
| 2–5 | 59 (71.1) | 24 (28.9) | |
| 6–10 | 32 (72.7) | 12 (27.3) | |
| >10 | 79 (68.7) | 36 (31.3) | |
| N.A. | 5 | 3 | |
|
Tumour rupture | |||
| No | 187 (75.1) | 62 (24.9) | 0.044 |
| Yes | 40 (62.5) | 24 (37.5) | |
|
Mutation site | |||
| KIT | 176 (72.4) | 67 (27.6) | |
| Exon 9 | 17 | 5 | |
| Exon11 | 156 | 60 | |
| Exon 13 | 3 | 2 | |
| PDGFRA | 25 (65.8) | 13 (34.2) | |
| Wild type for KIT and PDGFRA | 19 (79.2) | 5 (20.8) | 0.506 |
Abbreviations: HPF, high power field of a microscope; N.A., not available; PDGFRA, platelet-derived growth factor receptor alpha gene.