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. 2017 Mar 30;116(9):1239–1246. doi: 10.1038/bjc.2017.85

Table 2. Association between post-diagnosis sleep duration and mortality (N=3682).

  Model 1
Model 2
Model 3
Hours of sleep per night (deaths/N) HR (95% CI) HR (95% CI) HR (95% CI)
All-cause deaths (976 deaths)            
⩽6 h (257/965) 1.03 (0.87–1.22) 1.01 (0.86–1.20) 1.05 (0.88–1.24)
7 h (315/1234) 0.97 (0.82–1.14) 0.96 (0.82–1.13) 1.00 (0.85–1.18)
8 h (292/1100) 1 (reference)
⩾9 h (112/383) 1.45 (1.16–1.80) 1.40 (1.12–1.74) 1.37 (1.10–1.71)
P-value for non-linear trend 0.0008 0.009 0.02
Breast cancer deaths (412 deaths)            
⩽6 h (100/965) 1.07 (0.82–1.40) 1.10 (0.84–1.44) 1.13 (0.86–1.48)
7 h (143/1234) 1.09 (0.86–1.39) 1.07 (0.84–1.36) 1.10 (0.86–1.40)
8 h (124/1100) 1 (reference)
⩾9 h (45/383) 1.49 (1.05–2.10) 1.46 (1.03–2.07) 1.46 (1.02–2.07)
P-value for non-linear trend 0.13 0.11 0.12
Non-breast cancer deaths (564 deaths)            
⩽6 h (157/965) 1.03 (0.83–1.28) 0.98 (0.79–1.23) 1.01 (0.81–1.27)
7 h (172/1234) 0.90 (0.73–1.11) 0.89 (0.72–1.10) 0.90 (0.73–1.12)
8 h (168/1100) 1 (reference)
⩾9 h (67/383) 1.40 (1.05–1.87) 1.37 (1.03–1.83) 1.34 (1.01–1.79)
P-value for non-linear trend 0.003 0.02 0.03

Abbreviations: BMI=body mass index; CI=confidence intervals; HR=hazard ratio; OC=oral contraceptive; PMH=postmenopausal hormone.

Model 1: year of diagnosis, age at diagnosis, time since diagnosis, cancer stage, surgery, chemotherapy, radiation therapy, hormone therapy, prevalent diabetes or heart disease, missing indicators for oncologic treatments.

Model 2: Model 1+age, marital status, education level, income, OC use, number of pregnancies, family history of breast cancer, menopausal status, PMH use.

Model 3: Model 2+BMI, alcohol consumption, smoking, caffeine, calories intake, physical activity.

Sample includes women who received a breast cancer diagnosis and completed either the 1986, 2000, 2002, or 2008 sleep duration assessment ⩽4 years after. Bold characters indicate statistically significant results. Italic characters indicate the reference group.