Table 2. Association between post-diagnosis sleep duration and mortality (N=3682).
|
Model 1 |
Model 2 |
Model 3 |
||||
|---|---|---|---|---|---|---|
| Hours of sleep per night (deaths/N) | HR | (95% CI) | HR | (95% CI) | HR | (95% CI) |
| All-cause deaths (976 deaths) | ||||||
| ⩽6 h (257/965) | 1.03 | (0.87–1.22) | 1.01 | (0.86–1.20) | 1.05 | (0.88–1.24) |
| 7 h (315/1234) | 0.97 | (0.82–1.14) | 0.96 | (0.82–1.13) | 1.00 | (0.85–1.18) |
| 8 h (292/1100) | 1 (reference) | |||||
| ⩾9 h (112/383) | 1.45 | (1.16–1.80) | 1.40 | (1.12–1.74) | 1.37 | (1.10–1.71) |
| P-value for non-linear trend | 0.0008 | 0.009 | 0.02 | |||
| Breast cancer deaths (412 deaths) | ||||||
| ⩽6 h (100/965) | 1.07 | (0.82–1.40) | 1.10 | (0.84–1.44) | 1.13 | (0.86–1.48) |
| 7 h (143/1234) | 1.09 | (0.86–1.39) | 1.07 | (0.84–1.36) | 1.10 | (0.86–1.40) |
| 8 h (124/1100) | 1 (reference) | |||||
| ⩾9 h (45/383) | 1.49 | (1.05–2.10) | 1.46 | (1.03–2.07) | 1.46 | (1.02–2.07) |
| P-value for non-linear trend | 0.13 | 0.11 | 0.12 | |||
| Non-breast cancer deaths (564 deaths) | ||||||
| ⩽6 h (157/965) | 1.03 | (0.83–1.28) | 0.98 | (0.79–1.23) | 1.01 | (0.81–1.27) |
| 7 h (172/1234) | 0.90 | (0.73–1.11) | 0.89 | (0.72–1.10) | 0.90 | (0.73–1.12) |
| 8 h (168/1100) | 1 (reference) | |||||
| ⩾9 h (67/383) | 1.40 | (1.05–1.87) | 1.37 | (1.03–1.83) | 1.34 | (1.01–1.79) |
| P-value for non-linear trend | 0.003 | 0.02 | 0.03 | |||
Abbreviations: BMI=body mass index; CI=confidence intervals; HR=hazard ratio; OC=oral contraceptive; PMH=postmenopausal hormone.
Model 1: year of diagnosis, age at diagnosis, time since diagnosis, cancer stage, surgery, chemotherapy, radiation therapy, hormone therapy, prevalent diabetes or heart disease, missing indicators for oncologic treatments.
Model 2: Model 1+age, marital status, education level, income, OC use, number of pregnancies, family history of breast cancer, menopausal status, PMH use.
Model 3: Model 2+BMI, alcohol consumption, smoking, caffeine, calories intake, physical activity.
Sample includes women who received a breast cancer diagnosis and completed either the 1986, 2000, 2002, or 2008 sleep duration assessment ⩽4 years after. Bold characters indicate statistically significant results. Italic characters indicate the reference group.