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. 2016 Oct 11;112(5):740–751. doi: 10.1038/ajg.2016.453

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Copyright © 2017 American College of Gastroenterology

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Plots of sensitivity and specificity against age for existing diagnostic cutoffs for advanced fibrosis for: (a) aspartate aminotransferase (AST)/alanine transaminase (ALT) ratio (0.8); (b) non-alcoholic fatty liver disease fibrosis score (NFS) (−1.445); (c) fibrosis 4 (FIB-4) score (1.3). These show a reduction in sensitivity and an increase in specificity with age.