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. 2016 Oct 11;112(5):740–751. doi: 10.1038/ajg.2016.453

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Copyright © 2017 American College of Gastroenterology

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Proposed algorithm for the use of the (a) non-alcoholic fatty liver disease (NAFLD) fibrosis score (NFS) and (b) fibrosis 4 (FIB-4) score to help diagnose or exclude advanced fibrosis patients using the age specific cutoffs. The NFS and FIB-4 scores are not suitable for patients aged <35 years. Existing thresholds as previously published should be used for those aged 35–65 years. The new lower thresholds derived and validated in the current paper are recommended for those aged ≥65 years. Existing upper cutoffs remain the same for those aged ≥65 years. A full color version of this figure is available at the American Journal of Gastroenterology journal online.