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(a) Digestion of 3′-F dsDNA (200 nM) by wild-type or ΔC68 hEXOG(monomrt) (150 nM). (b) Modelled hEXOG-ΔC68 showing loss of tape-measure and dsDNA specificity. (c) Endonuclease activity of hEXOG-ΔC68 and wild type on øX174 DNA (50 nM). (d) Quantification of c. Data represent the mean±s.e.m. of three independent experiments.
