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. 2017 May 3;8:15122. doi: 10.1038/ncomms15122

Figure 2. Mutation of MAIL1 mostly induces upregulation of transcripts at both PCGs and heterochromatic TEs.

Figure 2

(a) Fraction and number of TEs and PCGs significantly up- (Up) or downregulated (Down) in mail1 seedlings versus WT. (b) Fraction of TEs and PCGs significantly upregulated in mail1 (mail1 up) located in euchromatin (eu.) or in pericentromeric heterochromatin (het.). Pericentromeric heterochromatin coordinates were assigned based on the distribution of repetitive elements, PCGs and DNA methylation across chromosomes as in ref. 2. Asterisks mark statistically significant differences from the distribution of total Arabidopsis thaliana TEs and PCGs (All, z-score=−2.68, P<0.01). (c) Overview of the five A. thaliana chromosomes showing the log2 ratios (mail1-1/WT) of mean RPKM values in 100 kb windows. The lower panel shows TE density in 100 kb windows, demonstrating the close correspondence between TE density and increased transcript accumulation in mail1-1 mutants.