Table 3.
Diagnostic accuracy of the noninvasive parameters of liver steatosis in the studied population using the imperfect gold standard methodology
| Parameter | Sensitivity (95% CI) |
Specificity (95% CI) |
PPV (95% CI) |
NPV (95% CI) |
Performance a |
|---|---|---|---|---|---|
| Analysis with the imperfect gold standard methodology: scenario 1 | |||||
| dCAP | 0.72 (0.64–0.79) |
0.98 (0.97–0.98) |
0.93 (0.90–0.96) |
0.89 (0.86–0.92) |
0.70 |
| Ultrasound | 0.46 (0.42–0.50) |
0.91 (0.89–0.92) |
0.68 (0.62–0.73) |
0.80 (0.78–0.81) |
0.37 |
| Fatty Liver index | 0.73 (0.72–0.74) |
0.27 (0.25–0.28) |
0.30 (0.29–0.31) |
0.7 (0.69–0.7) |
0 |
| BMI + AST and/or ALT | 0.75 (0.73–0.77) |
0.57 (0.55–0.60) |
0.43 (0.41–0.45) |
0.84 (0.82–0.86) |
0.22 |
| Analysis with the imperfect gold standard methodology: scenario 2 | |||||
| dCAP | 0.72 (0.69–0.78) |
1.00 (1.00–1.00) |
0.99 (0.99–1) | 0.89 (0.88–0.91) |
0.72 |
| Ultrasound | 0.43 (0.38–0.50) |
0.99 (0.99–1.00) |
0.96 (0.94–0.98) |
0.8 (0.78–0.82) |
0.42 |
| Hepatic Steatosis Index | 0.85 (0.84–0.85) |
0.33 (0.32–0.35) |
0.35 (0.34–0.36) |
0.83 (0.82–0.84) |
0.18 |
| BMI + AST and/or ALT | 0.73 (0.69–0.77) |
0.73 (0.69–0.77) |
0.54 (0.49–0.58) |
0.86 (0.84–0.88) |
0.54 |
PPV positive predictive value; NPV negative predictive value; CI 95% Credible Interval; dCAP dichotomized controlled attenuation parameter; BMI body mass index; AST aspartate aminotransferase; ALT alanine aminotransferase
a Performance = Sensitivity + Specificity - 100