Table 4.
Median time to 50 and 90% parasite reduction and recurrent infections up to day 28 (Study 1)
| Group | 1A | 1B | 1C | 1D |
|---|---|---|---|---|
| N | 34 | 30 | 30 | 19 |
| Median time (h) to 50% parasite reduction (95% CI) | 18.0 (12.0–24.0) | 18.0 (6.0–24.0) | 9.0 (6.0–18.0) | 24.0 (12.0–24.0) |
| Median time (h) to 90% parasite reduction (95% CI) | 30.0 (18.0–30.0) | 24.0 (12.0–36.0) | 30.0 (18.0–30.0) | 24.0 (24.0–30.0) |
| Recurrences | 14 | 13 | 15 | 8 |
| PCR data available | 12/14 | 11/13 | 10/15 | 8/8 |
| New infection | 9 (75%) | 6 (54.5%) | 6 (60%) | 0 |
| Recrudescences | 3 (25%) | 5 (45.5%) | 4 (40%) | 8 (100%) |
Recurrent infections were only analyzed in patients who were judged as successfully treated after 72 h
Group 1A: 1 day IM to adults; Group 1B: 3 days IM to adults; Group 1C: 1 day IV to adults; Group 1D: 3 days IM to children