Table 1.

Costs of biologic drugs used to treat psoriasis, including the initial year of therapy, maintenance dosing, and escalated dosing

	Initial Dosing	1st Year Cost of Therapy	Maintenance Dosing	Annual Cost	Escalated Dosing	Annual Cost
Etanercept	50 mg twice weekly for 3 months, then 50 mg weekly	$67,386	50 mg weekly	$53,909	50 mg twice weekly	$107,818
Adalimumab	80 mg once, then 40 mg every other week	$58,045	40 mg every other week	$53,899	40 mg weekly	$107,798
Ustekinumab	≤ 100 kg: 45 mg at weeks 0 & 4, then every 12 weeks	$58,966	45 mg every 12 weeks	$39,311	90 mg every 12 weeks	$78,622
	> 100 kg: 90 mg at Week 0 and Week 4, then every 12 weeks	$117,933	90 mg every 12 weeks	$78,622	90 mg every 8 weeks	$117,933
Secukinumab	300 mg weekly for 5 weeks, then 300 mg every 4 weeks	$70,195	300 mg every 4 weeks	$57,033
			Option to decrease to 150 mg every 4 weeks	⁎$28,517
Ixekizumab	160 mg once, then 80 mg every 2 weeks for 12 weeks, then 80 mg every 4 weeks	$83,714	80 mg every 4 weeks	$59,093	80 mg every 2 weeks	$118,185

Notes: Prices reflect average wholesale prices and may not include negotiated rebates or other discounts. Actual patient copays may be discordant with health system costs.

^⁎The 150 mg package is the same price as the 300 mg package, but the 300 mg package could theoretically be split into two 150 mg doses to decrease costs.