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. 2016 Dec 10;2(4):128–139. doi: 10.1016/j.ijwd.2016.10.003

Table 3.

Previous responsiveness studies in dermatology

Instrument Authors Year Sample Size Method for Responsiveness
EBDASI Jain et al. 2016 36 Utilized distribution and anchor-based methods.
Distribution-based: Mean change of scores, standardized response mean, and standardized effect size utilized to illustrate the magnitude of change in activity and damage scores.
Anchor-based: Pearson’s correlation coefficient utilized to determine the degree of correlation between change in EBDASI score and Likert scale of change.
BPDAI Wijayanti et al. 2016 32 Physician subjective assessment: improved, stable, deteriorated. Paired t test with BPDAI to note statistical significance. To be responsive ➔ statistically significant between improved and deteriorated, not statistically significant when stable.
BPDAI Patsatsi et al. 2012 39 Correlated BPDAI to BP180 titers at baseline, 3-month, and 6-month interval using Spearman’s rho correlation.
CLASI Bonilla-Martinez et al. 2008 8 Utilized: correlations, linear regressions, and Wilcoxon rank sum and 1-sided signed rank exact tests
The difference between baseline score and day 56 (change scores) were recorded for CLASI activity and damage, and each correlated via Pearson correlation coefficient with the change score of
  • 1)

    Physicians assessment of patient’s global skin health

  • 2)

    Patients self-assessment of global skin health

  • 3)

    Pain

  • 4)

    Itch
CDASI Goreshi et al. 2012 35 Included the two consecutive visits with the greatest variance in PGA-activity for analysis. Responsiveness was measured via Standardized Response Mean (SRM), SRM = ratio of the mean differences (i.e., CDASI score before and after clinical change was noted) to the standard deviation of the differences
EASI Breuer et al. 2004 Pimecrolimus (n = 129)
Control (n = 66)		 Following treatment with 1% pimecrolimus, EASI, IGA, SCORAD dropped significantly compared to the vehicle/control group as was depicted by t-test. Between-group comparisons established via Cochran-Mantel-Haenzel test.
Close correlation between pairs of EASI, IGA, and SCORAD depicted via Pearson test.
EASI, SCORAD Schram et al. 2012 143 Mean scores of EASI and SCORAD were correlated to mean scores of IGA and PGA within each treatment group per time point. Then ROC was utilized.

BPDAI = Bullous Pemphigoid Disease Area Index; CDASI = Cutaneous Dermatomyositis Disease Area and Severity Index; CLASI = Cutaneous Lupus Erythematosus Disease Area and Severity Index; EBDASI = Epidermolysis Bullosa Disease Activity and Scarring Index; EASI = Eczema Acvitity and Scarring Index; IGA = investigator global assessment; PGA = physcian global assessment; ROC = receiver operating characteristic; SCORAD = Scoring Atopic Dermatitis.