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Hypothetical model of the interaction of MRAP with the MC2R. MRAP (red) forms an antiparallel homodimer within the ER. This homodimer interacts with the MC2R (purple), possibly assisting its folding into an appropriate conformation. After further posttranslational modification in the ER and Golgi, the heterotrimeric structure then traffics to the cell surface, where it is capable of recognizing and responding to the ACTH peptide.
