Fig. 8.
DPN had no effect of KATP channel activity in GC-A KO mice. A, 1 nm DPN decreased KATP channel activity in intact pancreatic islet cells from WT mice. The records show KATP channel activity before DPN application and 5 min after application. B, Percentage of KATP channel activity in the presence of vehicle, before application of stimuli (vehicle) (n =7), in the presence of 1 nm DPN (n =5) and 8 mm glucose (n =3). C, The same experiment as in A, but using β-cells from GC-A KO mice. D, Percentage of activity of similar experiments performed in A and C using β-cells from GC-A mice. Note that 1 nm DPN had no effect, whereas 8 mm glucose had a normal action (n =4). *, P < 0.05; **, P < 0.005. Student’s t test compared with control.