Table 4.
Fold change of genes regulated by EE vs. vehicle detected by genome-wide gene expression analysis and validated by qRT-PCR
| Gene name | TaqMan probe | Gene ID | 4 h wt | 4 h mut | 24 h wt | 24 h mut |
|---|---|---|---|---|---|---|
| Leukemia-inhibitory factor receptor (Lifr) | Mm00442940_m1 | NM_013584.1 | 5.2 | 1.0 | 3.2 | 1.0 |
| (5.9 × 10−5) | (0.909) | (0.068) | (0.769) | |||
| IL-17 receptora (Il17ra) | Mm00434214_m1 | NM_008359.1 | 5.9 | 1.0 | 4.6 | 0.8 |
| (2.11 × 10−7) | (0.742) | (0.073) | (0.130) | |||
| Monocyte to macrophage differentiation-associated 2 (Mmd2) | Mm00558356_m1 | NM_175217.6 | 3.6 (4.27 × 10−4) | 0.7 (0.535) | 7.1 (0.181) | 0.9 |
| Transglutaminase 2 (Tgm2) | Mm00436980_m1 | NM_009373.3 | 2.9 | 0.9 | 5.9 | 1.0 |
| (8.25 × 10−5) | (0.368) | (0.079) | (0.499) | |||
| Growth differentiation factor 15 (Gdf15) | Mm00442228_m1 | NM_011819.1 | 10.8 | 0.5 | 4.5 | 1.3 |
| (7.14 × 10−5) | (0.432) | (0.260) | (0.683) | |||
| Coagulation factor III (F3) | Mm00438853_m1 | NM_010171.2 | 1.2 | 0.9 | 2.5 | 1.0 |
| (0.202) | (0.650) | (0.126) | (0.862) | |||
| Presenilin 2 (Psen2) | Mm00448405_m1 | NM_011183.1 | 2.1 | 1.2 | 2.3 | 1.1 |
| (5.21 × 10−5) | (0.733) | (0.056) | (0.566) | |||
| Wingless-related MMTV integration site 4 (Wnt4) | Mm00437341_m1 | NM_009523.1 | 1.0 | 1.1 | 1.1 | 1.1 |
| (0.970) | (0.475) | (0.406) | (0.153) | |||
| Progesterone receptor (Pgr) | Mm00435625_m1 | NM_008829.2 | 1.0 | 1.0 | 0.9 | 1.0 |
| (0.648) | (0.702) | (0.888) | (0.554) | |||
| IGF-1 (Igf-1) | Mm00439561_m1 | NM_001111274.1 | 1.0 | 1.0 | 0.7 | 0.9 |
| NM_001111275.1 | (0.658) | (0.887) | (0.060) | (0.177) | ||
| NM_001111276.1 |
ID, Identification; MMTV, murine mammary tumor virus; mut, mutant; wt, wild type. P values are in parentheses.