Table 2.
Examples of oncogenes and tumour suppressor genes
Activating (oncogenes) | Inactivating (tumour suppressor genes) |
B-RAF | Tumour protein (TP53) |
Phosphoinositide 3-kinase (PI3K) isoforms | Retinoblastoma associated (RB) |
Rat sarcoma (RAS) | Mammalian target of rapamycin (mTOR) |
Epidermal growth factor receptor (EGFR) | Phosphatase and tensin homolog (PTEN) |
Platelet derived growth factor receptor A (PDGFRA)
|
Breast cancer1 (BRCA1) |