Table 1. miRNAs associated with Bladder cancer .

MicroRNA	Chromosome location	Level	Sample	Target gene	Biological role	Clinical significance
Mir-21	Chr 17:57918627-57918698	Increase	Fresh tissue and bladder cell lines	P53, AKT, PTEN	Apoptosis, mesenchymal transition	Diagnostic, prognostic
Mir-18396-182 cluster	Chr 7: 129414745-129414854 Chr 7: 129414532-129414609 Chr 7: 129410223-129410332	Increase	Fresh tissue ,urine and bladder cell lines	PI3K/AKT/mTOR pathway	Cell growth, migration, apoptosis	Diagnostic, prognostic
Mir-29c	Chr 1: 207975197-207975284	Decrease	Fresh tissue and FFPE	methyltransferase	Maintain normal methylation profile	Stratificationfor high and low risk groups,goodprognosis
Mir-210	Chr 11: 568089-568198	Increase	Tissue and bladder cell lines	E2F3, FGFRL1, HOXA1	Cell growth, migration, apoptosis	Diagnostic, prognostic
Mir-124	Chr 20: 61809852-61809938	Decrease	Tissue and bladder cell lines	ROCK1	Migration and invasion	Biomarker for Diagnostics or prediction the response to therapy
Mir-409	Chr 14: 101531637-101531715	Decrease	Tissue and bladder cell lines	c-Met and c-Fos	Migration and invasion	prognostic
Mirs-23bfamily	chr 9: 9784749097847586	Decrease	Fresh tissue and FFPE	ZEB1	Epithelial-mesenchymal transition	Therapeutic target
Mirs200famil y	Chr 12: 7072862-7072929	Decrease	Tissue,serum and urine	ZEB1, ZEB2 and ERFF-1	Epithelial-mesenchymal transition	Diagnostic, prognostic
Mir-205	Chr 1: 209605478-209605587	Increase	Tissue and urine	PTEN, AKT, VEGF	Apoptosis cell cycle invasion, Epithelial-mesenchymal transition	Prognostic, therapeutic target
Mir-214	Chr 1: 172107938-172108047	Decrease	Tissue,serum and urine	B-catenin	Inhibition of cell proliferation, migration and invasion	Diagnostic, prognostic
Mir-5903p	Chr 7: 73605528-73605624	Decrease	Fresh tissue	TFAM, (PI3K), AKT, MMP2 and MMP9	Tumorogenesis	Therapeutic target

Abbreviation: Chr: Chromosome. FFPE: Formalin-fixed paraffin embedded