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Oncogenic Ras early inhibits TSHr pathway. A and B, Cl11 and FRTL-5 cells were treated with 4OHT for the reported time and analyzed by Western blot. A, TSHr expression analysis; ERRAS shows accumulation of the inducible oncoprotein. Actin is used to normalize for protein loading. B, Total CREB and phospho-CREB Ser133 (pCREB) analysis.
