Table 3.
Metabolic modifications in LXRα−/−β−/− mice during dietary challenge
| Standard chow diet | Western diet + CH | Western diet no CH | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex | Age (m) | Ref | Sex | Age (m) | Ref | Sex | Age (m) | Ref | |||||||||||||
| Body weight | Reduced | MF | 4–5–12 | (41 43 ) | Reduced | M | 4–5 | (42 ) | Unchanged | M | 4–5 | (42 ) | |||||||||
| Perigonadal fat | Reduced | MF | 12–18 | (38 41 43 ) | – | – | – | – | – | – | – | – | |||||||||
| Food intake | normal | MF | 12 | (43 ) | Unchanged | M | 4–5 | (42 ) | Unchanged | M | 4–5 | (42 ) | |||||||||
| Fat absorption | Reduced | M | 4–5 | (42 ) | Unchanged | M | 4–5 | (42 ) | Unchanged | m | 4–5 | (42 ) | |||||||||
| Serum insulin | Reduced | M | 4–5 | (42 ) | Tendency to be reduced | M | 4–5 | (42 ) | – | – | – | – | |||||||||
| Hepatic Triglyceride | Reduced | – | 4 | (39 ) | Reduced | M | 4–5 | (42 ) | – | – | – | – | |||||||||
| Hepatic Cholesterol | Increased | – | 4 | (39 ) | Increased | M | 4–5 | (42 ) | – | – | – | – | |||||||||
| Serum cholesterol | Normal | – | 4 | (39 ) | Tendency to be reduced | M | 4–5 | (42 ) | – | – | – | – | |||||||||
| LDL | Incresed | – | 4 | (39 ) | Increased | M | 4–5 | (42 ) | – | – | – | – | |||||||||
| HDL | tendency to be reduced | – | 4 | (39 ) | – | – | – | – | – | – | – | – | |||||||||
| LDL/HDL ratio | Increased | – | 4 | (39 ) | – | – | – | – | – | – | – | – | |||||||||
| Serum Triglycerides | Reduced | – | 4 | (39 ) | Reduced | M | 4–5 | (42 ) | – | – | – | – | |||||||||
| TSH | Normal | M | 4–5 | (42 ) | – | – | – | – | – | – | – | – | |||||||||
| T3 | Normal | M | 4–5 | (42 ) | – | – | – | – | – | – | – | – | |||||||||
| T4 | Normal | M | 4–5 | (42 ) | – | – | – | – | – | – | – | – | |||||||||
| Leptin | Normal / lower | F | 12 | (3842 ) | Tendency to be reduced | M | 4–5 | (42 ) | – | – | – | – | |||||||||
| Adiponectin | Reduced | F | 12 | (38 ) | – | – | – | – | – | – | – | – | |||||||||
| Resistin | normal | F | 12 | (38 ) | – | – | – | – | – | – | – | – | |||||||||