Fig. 2.

Functional analysis of all predicted mRNA targets of the 22 differentially expressed miRNAs in endometriosis. A, The number of mRNA transcripts predicted to be targeted by the 22 differentially expressed miRNAs in ectopic vs. eutopic endometrium from women with endometriosis. Seven miRNAs may each repress more than 200 mRNA transcripts, whereas five miRNAs had less than 30 anticipated targets. B, One of the molecular networks from IPA of all predicted targets of the 22 miRNAs incorporated molecules involved in cardiovascular system development and function, cellular movement, and cell morphology, including the validated miRNA target MEF2C. C, TGFβ2, SPARC, COL1A1, and COL1A2 are confirmed miRNA targets involved in extracellular matrix remodeling and cell invasion in an IPA network converging on interferon-γ. The gene names in these networks may be identified on the HUGO Gene Nomenclature Committee home page (http://www.genenames.org).