. 2009 Feb;23(2):265–275. doi: 10.1210/me.2008-0387

Table 2.

Experimentally confirmed regulatory functions of the 22 differentially expressed miRNAs in endometriosis

IPA Network (figure)	miRNA			miRNA target			Regulatory feedback loops	Confirmed biological functions	Proposed role in endometriosis	Ref. nos.
IPA Network (figure)		Gene	FC	mRNA	Reg		Regulatory feedback loops	Confirmed biological functions	Proposed role in endometriosis	Ref. nos.
CREBBP (Fig. 2B)	miR-223	↑	MEF2C	↑	MEF2C→ miR-1→\| HDAC4→\| MEF2C	miR-1 controls myogenesis and vascular development in association with MyoD family members	Cell migration, wound contraction, neovascularization in endometrial stromal myofibroblasts and pericytes	10 16 18 19 24 25
	miR-1	↑	HDAC4	↑				10 16
	miR-29c	↑	DNMT3A	↓		DNA methylation, tumorigenicity in lung cancer	DNA methylation, epigenetic regulation, gene expression	10 54
JUN (Fig 2A)	miR-29c	↑	SPARC, COL1A1, COL1A2	↑		Cell migration cancer metastasis	Extracellular matrix remodeling, cell invasion	10 23
	miR-141	↓	TGFβ2	↓		TGFβ-induced EMT	TGFβ-regulated stromal proliferation	10 33 55 56 57
CCND1 (S Fig. 3B)	miR-141, miR-200b	↓	ZEB1		ZEB1→\| miR-141 and miR-200b→\| ZEB1	TGFβ-induced EMT in cancer cell lines via targeting of TGFβ2, ZEB1 and ZEB2	Stromal fibroblast migration and invasion	20 21 22 33 58 59
	miR-141, miR-200b	↓	ZEB2	↑				10 20 21 22 59
	miR-20a	↓	CCND1	↑	miR-20a→\| CCND1→ miR-20a		Epithelial cell proliferation	10 60
	miR-20a	↓	E2F3	↑	E2F3→ miR-20a→\| E2F3		Cell proliferation and apoptosis	10 61
	miR-20a	↓	RUNX1	↑	miR-20a→\| RUNX1→\| miR-20a	Monocytopoiesis	Monocytic differentiation, proliferation, angiogenesis	10 62
PDGFBB/CXCL12 (S Fig. 3A)	miR-1	↑	FN1	↑		Cardiac hypertrophy, myocyte proliferation	Cell proliferation and migration, wound healing	10 63
NFκB (S Fig. 3D)	miR-20a	↓	CTGF	↑		Neovascularization in cancer	Neovascularization	10 64
	miR-1	↑	HSPD1	↓		Cardiomyocyte apoptosis	Apoptosis	10 65

S, Supplemental; C, fold change; Reg, miRNA regulation; ZEB1 and ZEB2, zinc finger E-box binding homeobox 1 and 2; E2F3, E2F transcription factor 3; RUNX1, runt-related transcription factor 1; FN1, fibronectin 1; CTGF, connective tissue growth factor; HSPD1, heat shock 60-kDa protein 1; EMT, epithelial to mesenchymal transition; ↑, up-regulated; ↓, down-regulated; →, positive regulation; →|, inhibition.