Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
LIF Treatment Accelerated Embryonic Lethality in SOCS−/− Embryo
| Genotyped on E11.5 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Total | +/+ | +/− | −/− | Viable−/−(%) | |||||
| Control | 88 | 19 (0) | 49 (0) | 20 (1) | 22% | ||||
| LIF treatment | 75 | 18 (7) | 51 (26) | 6 (6) (dead) | 0% | ||||
In SOCS3-deficient mice, until E11.5, SOCS3−/− embryos were viable. Strikingly, when LIF was administered to SOCS3 heterozygous pregnant mice, no viable SOCS3−/− embryos were detected on e11.5.
