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The JAK1−/− and +/− Backgrounds Rescued Placental Defects and Embryonic Lethality in SOCS3-Deficient Mice
| SOCS3 | |||||||
|---|---|---|---|---|---|---|---|
| +/+ | +/− | −/− | |||||
| JAK1 | +/+ | 4 | 7 | 0 | |||
| +/− | 11 | 20 | 10 (2) (dead) | ||||
| −/− | 3 | 5 | 4 | ||||
| SOCS3 heterozygous intercross | 55 | 106 | 0 | ||||
SOCS3-deficient embryos died around E12.5–E15.5, and no viable embryos were detected at term; however, viable SOCS3−/− embryos were detected at term (E18.5) in the JAK1−/− and +/− background.
