Fig. 9.

Negative Transcriptional Feedback Loop by Rev-erbα on the Selective LXR-Induced TLR-4 Pathway

Rev-erbα is a LXR target gene in human macrophages and represses LXR-induced-TLR-4 expression by binding to a RevRE overlapping with the previously described LXRE site. This cross talk between Rev-erbα and LXR together with the induction of Rev-erbα expression by LPS identifies Rev-erbα as a molecular link driving transcriptional feedback loops and as a crucial factor in the macrophage response to LPS.