Table 4. Multivariable robust Cox model results for the 34 top AMD risk variants on progression to late AMD.
| Variant | Chr | Major/minor allele | locus namea | Effect on progression (AREDS) | Effect on progression (AREDS2) | ||
|---|---|---|---|---|---|---|---|
| HR | P Value | HR | P Value | ||||
| rs10922109 | 1 | C/A | CFH | 0.69 | 7.2 × 10−9 | 1.09 | 0.19 |
| rs11884770 | 2 | C/T | COL4A3 | 1.02 | 0.69 | 0.86 | 1.2 × 10−2 |
| rs62247658 | 3 | T/C | ADAMTS9-AS2 | 1.09 | 9.9 × 10−2 | 0.88 | 9.5 × 10−3 |
| rs140647181 | 3 | T/C | COL8A1 | 1.64 | 4.8 × 10−2 | 0.98 | 0.91 |
| rs10033900 | 4 | C/T | CFI | 0.98 | 0.67 | 0.93 | 0.13 |
| rs62358361 | 5 | G/T | C9 | 1.06 | 0.82 | 0.67 | 5.4 × 10−2 |
| rs114092250 | 5 | G/A | PRLR/SPEF2 | 0.61 | 1.4 × 10−2 | 0.95 | 0.80 |
| rs116503776 | 6 | G/A | C2/CFB/SKIV2L | 0.75 | 1.6 × 10−3 | 0.95 | 0.61 |
| rs943080 | 6 | T/C | VEGFA | 0.94 | 0.20 | 0.96 | 0.37 |
| rs7803454 | 7 | C/T | PILRB/PILRA | 1.00 | 0.99 | 1.21 | 2.5 × 10−3 |
| rs1142 | 7 | C/T | KMT2E/SRPK2 | 1.01 | 0.83 | 1.05 | 0.36 |
| rs79037040 | 8 | T/G | TNFRSF10A | 0.95 | 0.28 | 0.96 | 0.42 |
| rs71507014 | 9 | GC/G | TRPM3 | 0.99 | 0.86 | 0.90 | 2.8 × 10−2 |
| rs10781182 | 9 | G/T | MIR6130/RORB | 0.88 | 2.0 × 10−2 | 0.90 | 3.6 × 10−2 |
| rs1626340 | 9 | G/A | TGFBR1 | 0.92 | 0.24 | 0.94 | 0.32 |
| rs2740488 | 9 | A/C | ABCA1 | 0.99 | 0.81 | 1.04 | 0.52 |
| rs12357257 | 10 | G/A | ARHGAP21 | 1.07 | 0.26 | 1.10 | 0.11 |
| rs3750846 | 10 | T/C | ARMS2/HTRA1 | 1.44 | 1.3 × 10−11 | 1.22 | 5.9 × 10−5 |
| rs3138141 | 12 | C/A | RDH5/CD63 | 1.18 | 4.4 × 10−2 | 0.96 | 0.58 |
| rs61941274 | 12 | G/A | ACAD10 | 1.14 | 0.50 | 1.00 | 0.98 |
| rs9564692 | 13 | C/T | B3GALTL | 0.83 | 1.6 × 10−3 | 0.94 | 0.24 |
| rs61985136 | 14 | T/C | RAD51B | 1.17 | 6.6 × 10−3 | 0.98 | 0.76 |
| rs2043085 | 15 | T/C | LIPC | 1.14 | 1.2 × 10−2 | 0.99 | 0.88 |
| rs5817082 | 16 | C/CA | CETP | 0.90 | 6.8 × 10−2 | 1.08 | 0.22 |
| rs72802342 | 16 | C/A | CTRB2/CTRB1 | 0.79 | 6.3 × 10−2 | 0.89 | 0.32 |
| rs11080055 | 17 | C/A | TMEM97/VTN | 1.11 | 3.3 × 10−2 | 1.08 | 0.13 |
| rs6565597 | 17 | C/T | NPLOC4/TSPAN10 | 1.04 | 0.48 | 1.01 | 0.79 |
| rs67538026 | 19 | C/T | CNN2 | 0.89 | 3.2 × 10−2 | 0.90 | 9.4 × 10−2 |
| rs2230199 | 19 | C/G | C3 | 0.86 | 1.6 × 10−2 | 0.97 | 0.64 |
| rs429358 | 19 | T/C | APOE | 0.95 | 0.56 | 1.03 | 0.73 |
| rs142450006 | 20 | TTTTC/T | MMP9 | 0.76 | 1.7 × 10−3 | 0.76 | 8.9 × 10−4 |
| rs201459901 | 20 | T/TA | C20orf85 | 1.05 | 0.61 | 0.90 | 0.38 |
| rs5754227 | 22 | T/C | SYN3/TIMP3 | 0.90 | 0.19 | 0.75 | 3.3 × 10−4 |
| rs8135665 | 22 | C/T | SLC16A8 | 0.99 | 0.86 | 1.02 | 0.79 |
Model was adjusted for baseline age, education, smoking status, and study eye’s baseline AMD severity score.
a
The locus name is a label of the region using the nearest gene(s), but does not necessarily state the responsible gene.