Figure 3.
Gαq/0 signaling is required for the hyperactive phenotype of twk-7(null) mutants. (A) The bending frequencies and (B) crawling velocities of single and double mutant animals during spontaneous crawling are shown. (C) The spontaneous locomotion behavior was divided into periods of crawling forward (f), crawling backward (b), and dwelling (d). All values represent the mean (± SEM) of at least N ≥ 3 independent experiments involving n ≥ 30 never-starved animals. Dotted lines indicate the wild-type level. *P < 0.05, **P < 0.01, and ***P < 0.001 (Student’s t-test). BBCF, body-bending crawling frequency.