Table 3. We infer more nearly neutral (|s| < 10−5) and fewer strongly deleterious (|s| ≥ 10−2) new mutations than previous studies.
Data set | μ, LNS/LS | Best fit DFE | 0 ≤ |s| < 10−5 | 10−5 ≤ |s| < 10−4 | 10−4 ≤ |s| < 10−3 | 10−3 ≤ |s| < 10−2 | 10−2 ≤ |s| |
---|---|---|---|---|---|---|---|
Boyko et al. (2008) (AAa) | 1.8 × 10−8, 2.5b | Gamma | 0.183 | 0.096 | 0.147 | 0.219 | 0.355 |
1000 Genomes | 1.8 × 10−8, 2.5b | Gamma | 0.217 (0.212–0.223) | 0.112 (0.111–0.113) | 0.169 (0.165–0.172) | 0.243 (0.235–0.249) | 0.259 (0.252–0.266) |
ESP | Gamma | 0.229 (0.223–0.234) | 0.105 (0.104–0.106) | 0.152 (0.150–0.155) | 0.216 (0.212–0.221) | 0.298 (0.294–0.302) | |
LuCamp | Discrete | 0.278 (0.221–0.303) | 0.027 (0.001–0.110) | 0.211 (0.167–0.234) | 0.352 (0.330–0.373) | 0.132 (0.124–0.142) | |
1000 Genomes | 1.5 × 10−8, 2.31 | Gamma | 0.237 (0.231–0.243) | 0.127 (0.125–0.128) | 0.192 (0.188–0.197) | 0.266 (0.259–0.272) | 0.178 (0.171–0.186) |
ESP | Neu+gamma | 0.263 (0.250–0.277) | 0.104 (0.091–0.114) | 0.167 (0.160–0.173) | 0.249 (0.241–0.259) | 0.217 (0.211–0.221) | |
LuCamp | Neu+gamma | 0.242 (0.223–0.260) | 0.091 (0.072–0.107) | 0.194 (0.183–0.203) | 0.332 (0.313–0.352) | 0.141 (0.129–0.152) |
Results in comparison with data from Boyko et al. (2008). C.I.’s were constructed by Poisson resampling the nonsynonymous SFS and fitting a DFE 200 times. See Table S5 in File S1 for additional information. Neu, neutral.
African-American.
The results presented with the assumptions LNS/LS = 2.5 and μ = 1.8 × 10−8 match the mutation rate assumptions of Boyko et al. (2008).