Figure 6.

Mutations in the Mre11 dimerization domain, but not the nuclease domain, reduce NHEJ. Strains bearing the Hermes insertion and the indicated mre11 mutations were tested in the excision assay as in Figure 2 and Figure 4. The indicated median excision frequencies and excision footprint sequences are shown in Figure 7 and Figure S7 in File S1, respectively. NHEJ, nonhomologous end-joining; wild-type, WT.