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. 2017 May 5;12(5):e0177077. doi: 10.1371/journal.pone.0177077

Fig 1. Action of APHCs on capsaicin-induced TRPV1 currents.

Fig 1

A-F, Reversible inhibition or potentiation of currents evoked by 3 μM (panels A, B and C) or 0.3 μM (panels D, E and F) capsaicin by 100 nM APHC1 (panels A, D), APHC2 (panels B, E) and APHC3 (panel C, F). G, Current–voltage relationship for TRPV1 currents induced by 3 and 0.3 μM capsaicin in control (black and red) and in the presence of 100 nM APHC1 (blue and magenta). In both cases the toxin effect is voltage-independent. H, Concentration-dependence of an inhibition of TRPV1 currents activated by 3 μM capsaicin, n = 7 for each ligand. I, Summary of the polypeptides action (100 nM) on TRPV1 responses activated by different concentrations of capsaicin, n = 9 for all series. (*)—reliable effect by ANOVA, p = 0.05. (drug vs control).