Fig 4. Relative effect of APHC3 on TRPV1 currents in response to single and multiple stimuli activation.
Effect of 100 nM APHC3 on TRPV1 currents evoked by co-application of capsaicin and 2APB (A), or capsaicin and low pH (B), traces of cell responses in control and at peptide application are shown. C, Summary of the data. The values are given as mean ± SD. Reliability to control (*) was checked by ANOVA followed by Tukey’s post hoc analysis, p = 0.05. Effect on capsaicin-evoked response (n = 9) to co-application of capsaicin and low pH (n = 6) was not statistically different. Effect on 2APB alone (n = 7) to 2APB plus capsaicin (n = 6) was not statistically different.