Table 1.

Effect of U0126 on the Activation of ERK1/2 Stimulated by BDNF

	None	BDNF	BDNF + U0126	U0126
pERK1	0.26 ± 0.14	1.001	0.39 ± 0.322	0.18 ± 0.15
pERK2	0.37 ± 0.21	1.001	0.51 ± 0.272	0.21 ± 0.16
ERK1	0.90 ± 0.12	1.00	1.13 ± 0.32	1.28 ± 0.47
ERK2	0.90 ± 0.12	1.00	0.97 ± 0.52	1.00 ± 0.18

Each band was quantified by densitometry after Western blot analysis. U0126 and BDNF were applied as indicated in Fig. 7A. To quantify Western blot, normalization using the response to exogenous BDNF application was performed. Data represent the mean ± sd (n = 5).

¹P < 0.01 (none vs. BDNF), Kruskal-Wallis test and Mann-Whitney U test.

²P < 0.01 (BDNF vs. BDNF plus U0126), Kruskal-Wallis test and Mann-Whitney U test.