Fig. 1.

Structure of GSK0660 and Its Activity in Primary Human Skeletal Muscle Cells

A, Structure of GSK0660, methyl 3-({[2-(methoxy)-4 phenyl]amino}sulfonyl)-2-thiophenecarboxylate. B, Effects of GW0742 and GSK0660 on gene expression in human skeletal muscle cells. GW0742 robustly induces the expression of known PPARβ/δ target genes, whereas GSK0660 reduces the basal level of gene expression for ANGPTL4 and CPT1a, but not PDK4 in a dose-responsive manner. Gene expression analysis was performed using Taqman. *, P < 0.05 by a t test.