Table 1. Baseline characteristics rats.
| Variable | SD | Ren2 | P-value |
|---|---|---|---|
|
Animal characteristics N = |
7–8 | 8 | |
| Body weight (g) | 395.0±28.4 | 365.9±43.0 | 0.128 |
| LV weight (mg) | 955.9±107.4 | 1389.0±173.7 | <0.001 |
| LV/BW ratio (mg/g) | 2.4±0.26 | 3.8±0.36 | <0.001 |
| Lung weight (mg) | 992.4±106.9 | 1194.0±310.9 | 0.120 |
| Lung/BW ratio (mg/g) | 2.51±0.31 | 3.3±0.89 | 0.048 |
|
Hemodynamic parameters N = |
8 | 7–8 | |
| Heart rate (beats/min) | 319.0±37.4 | 330.9±25.3 | 0.471 |
| Systolic blood pressure (mmHg) | 108.0±7.0 | 148.6±17.4 | <0.001 |
| LVEDP (mmHg) | 9.0±2.3 | 21.9±4.2 | <0.001 |
| dP/dtmax | 62.3±4.1 | 51.5±4.0 | <0.001 |
| Tau (ms) | 10.7±1.3 | 13.2±1.1 | 0.001 |
|
Cardiac stress markers N = |
8 | 7 | |
| ANP/36B4 | 0.04±0.04 | 1.45±0.51 | <0.001 |
| BNP/36B4 | 0.30±0.11 | 1.13±0.33 | <0.001 |
Values are presented as mean with standard deviation. SD indicates Sprague-Dawley; LV, left ventricle; BW, body weight; LVEDP, left ventricular end-diastolic pressure; ANP, atrial natriuretic peptide and BNP, B-type natriuretic peptide. dP/dtmax represents the maximum rise in LV pressure in early systole corrected for peak systolic pressure.