Table 1.
Comparison | Arm 1 response rate | Comparator response rate | Unadjusted Estimate | 95% Confidence Interval | Adjusted Estimatea | 95% Confidence Interval |
---|---|---|---|---|---|---|
Arm 2 – Arm 1b | 59.9% | 51.2% | −8.7% | −13.1, −4.4% | −8.5% | −12.7, −4.2% |
Arm 3 – Arm 1 | 59.9% | 51.9% | −8.0% | −12.4, −3.7% | −8.7% | −13.0, −4.4% |
Arm 4 – Arm 1 | 59.9% | 37.9% | −22.0% | −26.3, −17.7% | −23.2% | −27.5, −19.0% |
Adjusted for gender, race/ethnicity, age at diagnosis, year of diagnosis
Arm 1 is the gold standard.
For all comparisons, the lower equivalence margin (−5%) is within or above the 95% confidence interval; thus there is not enough evidence to reject the null hypothesis of inferiority.