Fig. 3.

Adaptation of Drosophila to DCV highlights the importance of restriction factors. a Flies grown for 20 generations under DCV infection show increased survival upon infection with the virus compared to controls. b Comparison of allele frequencies between control and virus-selected populations at generation 20 identified by genome-wide sequencing. The arrowheads indicate the localization of causal polymorphisms on the left arm of chromosome 3 and on chromosome X. CMH Cochran–Mantel–Haenszel test. c Schematic representation of the Pst and Ubc-E2H genes, with coding regions in green, and the location of polymorphism indicated in the exon 7 of Pst and in the intron of Ubc-E2H. a and b were redrawn and adapted from [140]