Table 1.

Precursor lesions of high-grade serous epithelial ovarian, fallopian tube, and peritoneal carcinomas

Pre-cancerous Lesions	Immunohistochemical Profile
p53 signature	no morphologic phenotype, p53+++ and Ki67<10%
proliferating p53 signature	no morphologic phenotype, p53+++ and Ki67>10%
STIC	atypical serous epithelium, p53+++ and Ki67+++, PAX2, yH2AX+, Laminin y1
SCOUT	Proliferation of Bcl2-positive secretory cells with loss of PAX2

STIC, serous tubal intraepithelial carcinoma

SCOUT, secretory cell overgrowth