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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Alcohol. 2016 Nov 5;60:169–177. doi: 10.1016/j.alcohol.2016.11.001

Figure 5. Paternal CIE increases sensitivity to acute ethanol selectively in male offspring.

Figure 5

(A) In the elevated plus maze, following an acute injection with 1 g/kg ethanol, E-sired males (n=11) spent more time in the open arm (% of total time) and made more (B) open arm entries (% of total entries) vs C-sired males (n=10). (C) ethanol injection increased total arm entries, but there was no difference between E-and C-sired males. There was no difference between E-sired and C-sired males for all elevated plus maze measures following saline injection (n=12 for E-sired; n=11 for C-sired). (D) There was no difference between E-sired (n=6) and C-sired (n=6) female mice for time in the open arm, (E) open arm entries, or (F) total arm entries following acute ethanol injection. Saline-treated E-sired and C-sired females (n=7 for E-sired; n=7 for C-sired) did not differ across all measures in the elevated plus maze. Data presented as mean ± SEM. *=p<0.05, **=p<0.01, ***=p<0.001.