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Level of block with 2:1 atrioventricular block poses a challenge. Clues that can suggest His-Purkinje disease versus atrioventricular nodal disease include bundle branch block and normal PR interval.
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During lower degree of block (eg, 3:2 or 4:3), the Wenckebach phenomenon can occur even at the His-Purkinje level.
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Syncope or sudden death in the setting of bradycardia can be due to torsade de pointes.