Table 2.
Rates per patient year (95% CI) and rate ratios (95% CI) of GP consultations, tests, prescriptions and referrals from 10 years before until 10 years after a first recorded diagnosis of CFS/ME in paediatric cases compared with controls
| Year −10 to −6 | Year −5 to −1 | Year 0 | Year 1 to 5 | Year 6 to 10 | |
|---|---|---|---|---|---|
| Total person years | |||||
| Cases | 2088 | 3715 | 916 | 3290 | 1076 |
| Controls | 1996 | 3591 | 916 | 3257 | 1077 |
| GP consultations | |||||
| Cases (rate) | 3.77 (3.69, 3.85) | 4.43 (4.36, 4.49) | 8.22 (8.04, 8.41) | 4.42 (4.35, 4.49) | 4.01 (3.89, 4.13) |
| Controls (rate) | 2.59 (2.52, 2.66) | 1.89 (1.84, 1.93) | 2.01 (1.91, 2.10) | 2.36 (2.31, 2.42) | 2.47 (2.38, 2.57) |
| Rate ratio | 1.45 (1.40, 1.51) | 2.34 (2.28, 2.41) | 4.10 (3.90, 4.31) | 1.87 (1.82, 1.92) | 1.62 (1.54, 1.70) |
| Diagnostic tests | |||||
| Cases (rate) | 1.42 (1.37, 1.47) | 8.44 (8.35, 8.54) | 29.4 (29.1, 29.8) | 10.3 (10.2, 10.4) | 11.8 (11.6, 12.0) |
| Controls (rate) | 0.53 (0.49, 0.56) | 1.21 (1.17, 1.24) | 2.28 (2.19, 2.38) | 3.90 (3.83, 3.97) | 5.00 (4.87, 5.14) |
| Rate ratio | 2.70 (2.51, 2.89) | 7.01 (6.79, 7.23) | 12.9 (12.3, 13.5) | 2.64 (2.59, 2.70) | 2.37 (2.29, 2.44) |
| Prescriptions | |||||
| Cases (rate) | 3.00 (2.93, 3.08) | 3.37 (3.31, 3.43) | 5.67 (5.52, 5.83) | 3.83 (3.77, 3.90) | 3.65 (3.54, 3.77) |
| Controls (rate) | 2.08 (2.02, 2.14) | 1.46 (1.42, 1.50) | 1.71 (1.62, 1.79) | 1.92 (1.88, 1.97) | 1.99 (1.91, 2.07) |
| Rate ratio | 1.44 (1.39, 1.50) | 2.31 (2.23, 2.38) | 3.33 (3.14, 3.52) | 1.99 (1.93, 2.05) | 1.84 (1.74, 1.93) |
| Referrals | |||||
| Cases (rate) | 0.25 (0.23, 0.27) | 0.43 (0.41, 0.45) | 1.28 (1.21, 1.35) | 0.42 (0.40, 0.44) | 0.39 (0.36, 0.43) |
| Controls (rate) | 0.18 (0.16, 0.20) | 0.14 (0.13, 0.15) | 0.15 (0.12, 0.17) | 0.16 (0.15, 0.17) | 0.16 (0.13, 0.18) |
| Rate ratio | 1.40 (1.22, 1.60) | 3.08 (2.79, 3.41) | 8.83 (7.38, 10.6) | 2.61 (2.36, 2.89) | 2.53 (2.12, 3.03) |