Table 3.
Rates (95% CI) of all symptoms and of fatigue symptoms and rate ratios (95% CI) from 15 years before (adults) or 10 years before (paediatric) until 10 years after a first recorded diagnosis of CFS/ME
| Year −15 to −11 | Year −10 to −6 | Year −5 to −1 | Year 0 | Year 1 to 5 | Year 6 to 10 | |
|---|---|---|---|---|---|---|
| Total adult person years | ||||||
| Cases | 4579 | 12,183 | 24,478 | 6710 | 25,447 | 10,815 |
| Controls | 4649 | 12,258 | 24,564 | 6710 | 25,038 | 10, 508 |
| Adults (all symptoms) | ||||||
| Cases (rate per patient year) | 1.14 (1.11, 1.17) | 1.53 (1.51, 1.55) | 2.46 (2.44, 2.48) | 3.19 (3.15, 3.23) | 2.35 (2.33, 2.37) | 2.40 (2.37, 2.43) |
| Controls (rate per patient year) | 0.67 (0.65, 0.70) | 0.98 (0.96, 1.00) | 1.30 (1.29, 1.32) | 1.36 (1.34, 1.39) | 1.41 (1.40, 1.43) | 1.55 (1.53, 1.57) |
| Rate ratio | 1.69 (1.62, 1.77) | 1.57 (1.53, 1.60) | 1.89 (1.87, 1.92) | 2.34 (2.28, 2.39) | 1.67 (1.65, 1.69) | 1.55 (1.52, 1.58) |
| Adults (fatigue symptoms) | ||||||
| Cases (rate per patient year) | 2.80 (2.31, 3.28) | 6.15 (5.71, 6.59) | 19.4 (18.9, 20.0) | 57.5 (55.7, 59.3) | 10.9 (10.5, 11.3) | 8.61 (8.06, 9.16) |
| Controls (rate per patient year) | 0.34 (0.18, 0.51) | 1.61 (1.38, 1.83) | 2.31 (2.12, 2.50) | 2.62 (2.24, 3.01) | 2.66 (2.45, 2.86) | 2.29 (2.00, 2.58) |
| Rate ratio | 8.12 (4.83, 13.7) | 3.83 (3.27, 4.48) | 8.40 (7.70, 9.16) | 21.9 (18.8, 25.5) | 4.10 (3.77, 4.46) | 3.75 (3.26, 4.32) |
| Total paediatric person years | ||||||
| Cases | 2088 | 3715 | 916 | 3290 | 1076 | |
| Controls | 1996 | 3591 | 916 | 3257 | 1077 | |
| Paediatric (all symptoms) | ||||||
| Cases (rate per 100 patient years) | 1.14 (1.10, 1.19) | 1.74 (1.70, 1.78) | 3.12 (3.01, 3.24) | 1.62 (1.58, 1.66) | 1.53 (1.46, 1.61) | |
| Controls (rate per 100 patient years) | 0.68 (0.64, 0.72) | 0.67 (0.64, 0.69) | 0.71 (0.66, 0.76) | 0.81 (0.78, 0.84) | 0.86 (0.80, 0.91) | |
| Rate ratio | 1.68 (1.57, 1.79) | 2.60 (2.48, 2.73) | 4.40 (4.04, 4.79) | 2.00 (1.91, 2.10) | 1.79 (1.65, 1.94) | |
| Paediatric (fatigue symptoms) | ||||||
| Cases (rate per 100 patient years) | 1.39 (0.88, 1.89) | 11.6 (10.5, 12.7) | 56.3 (51.5, 61.2) | 7.36 (6.43, 8.28) | 4.83 (3.52, 6.15) | |
| Controls (rate per 100 patient years) | 0.20 (0.00, 0.40) | 0.56 (0.31, 0.80) | 1.09 (0.42, 1.77) | 1.81 (1.35, 2.27) | 1.02 (0.42, 1.62) | |
| Rate ratio | 6.93 (2.44, 19.7) | 20.8 (13.3, 32.6) | 51.6 (27.6, 96.5) | 4.06 (3.05, 5.40) | 4.73 (2.47, 9.07) | |