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. Author manuscript; available in PMC: 2017 May 6.
Published in final edited form as: J Magn Reson Imaging. 2016 Jul 13;45(2):428–439. doi: 10.1002/jmri.25382

FIGURE 1.

FIGURE 1

Fatty liver and iron overload can occur concurrently. Accurate measurement of the proton density fat-fraction (PDFF) requires correcting for R2*, which is elevated as a result of the iron overload. (a) The spectrum at 1.5T has linewidths corresponding to R2*W = 159 s−1 and R2*F = 145 s−1, indicating iron overload. Quantification of PDFF from this spectrum resulted in 37%, corresponding to fatty liver. (b) The R2* map from imaging data at 1.5T is 166 s−1 within the rectangular ROI (colocalized to the spectroscopy voxel from (a)). (c) The PDFF map reconstructed from the same imaging source data as in (b) is 37% within the same ROI. Both the R2* map and the PDFF map were reconstructed using the single-R2* signal model (Eq. (2)). The close agreement between imaging PDFF and spectroscopy PDFF indicates that R2* correction of imaging PDFF was done accurately.