Single-R2* is more accurate than dual-R2* in Monte Carlo simulation when R2*F and R2*W are not very different in value, and especially when PDFF or SNR is low. Contours where single-R2* RMSE is equal to dual-R2* RMSE are shown for PDFF = 5, 10, 20, and 30% (all at SNR = 20) for (a) 1.5T, and (b) 3.0T. At low PDFF, the contours are far apart: single-R2* outperforms dual-R2* over most of the combinations of R2*F and R2*W. As PDFF grows, the contours become closer, and the area where single-R2* has better performance shrinks. (c) Increasing the SNR also moves the contours closer together. Contours are shown for SNR = 15 and 30, with PDFF = 20% and field strength of 1.5T and (d) 3.0T.