Table 3. SAR Study Results of Individual Compounds Synthesized Based on Positional Scan of Mixture Samples^a.

Sample #	STRUCTURE	R3	ADAM10 IC50, μM	ADAM 17 1C50, μM
Core		N/A	N/A	N/A
6		S-4-hydroxybenzyl	>100	5.9 ± 0.9
8		R-4-hydroxybenzyl	>100	5.4 ± 0.5
12		S-4-hydroxybenzyl	>100	8.1 ±0.9
13		R-4-hydroxybenzyl	>100	15 ±1.2
9		S-5-naphthalen-2-ylmethyl	>100	10 ± 0.8
10		R-5-naphthalen-2-ylmethyl	>100	7.9 ± 0.8
14		S-5-naphthalen-2-ylmethyl	>100	8.4 ± 1.0
15		R-5-naphthalen-2-ylmethyl	>100	5.7 ±1.0
11		S-5-butyl	>100	6.5 ± 0.9
16		S-5-butyl	>100	5.7 ± 0.8

^aR3 is scanned, and R1, R2, and R4 are fixed. IC₅₀ values data reported as a mean of three experiments ± standard deviation.