. Author manuscript; available in PMC: 2017 May 6.

Published in final edited form as: J Med Chem. 2015 Aug 4;58(15):5808–5824. doi: 10.1021/acs.jmedchem.5b00354

Table 4. Summary of Selectivity Testing of Novel ADAM17 Inhibitors against a Panel Zinc of Metalloproteases^a.

ID	MMP2	MMP8	MMP9	MMP14	ADAM10	ADAM17
16	>100	>100	>100	>100	>100	5.7 (100)
17	NT	> 100 (13)	NT	> 100 (25)	>100	4.2 (95)
18	>100	> 100 (28)	> 100 (13)	> 100 (27)	>100	5.4 (100)
19	>100	>100	>100	>100	>100	4.3 (100)
20	>100	>100	>100	>100	>100	11 (100)
21	>100	>100	>100	>100	>100	8.5 (100)

All results are IC₅₀, μM (%inhibition at 100 μM). No parentheses indicates 0% inhibition at 100 μM. NT: not tested.

Table 4. Summary of Selectivity Testing of Novel ADAM17 Inhibitors against a Panel Zinc of Metalloproteasesa.