Fig. 2.

Effects of LSD on the 5 Dimensions of Altered States of Consciousness (5D-ASC) scale. LSD mainly increased ratings of oceanic boundlessness (OB) and visionary restructuralization (VR), with significantly higher ratings for the ASC total score and VR dimension at 200 μg compared with 100 μg. LSD-induced increases in anxious ego dissolution (AED) and auditory alterations (AA) were relatively small. LSD also produced vigilance reduction (VIR). LSD-induced changes on the 5D-ASC scale were significant compared with placebo for both doses and all of the scales, with the exception of the effects of the 200 μg dose on anxiety (Table 1). At 200 μg, LSD produced significant and relevantly higher ratings of blissful state, insightfulness, and changed meaning of percepts compared with 100 μg (one asterisk p < 0.05, two asterisks p < 0.01, t tests). The data are expressed as the mean ± SEM in 24 subjects and 16 subjects for the 100 and 200 μg doses of LSD, respectively