Table 3.
Associations between predicted maximal LSD plasma concentrations (C max) and LSD exposure (AUC) and alterations in consciousness (SD-ASC) and mystical experiences (MEQ30)
| N = 24 | N = 16 | |||
|---|---|---|---|---|
| 100 μg | 200 μg | |||
| C max | AUC | C max | AUC | |
| 5D-ASC scale | ||||
| ASC total score | 0.19 | 0.21 | −0.35 | 0.15 |
| Oceanic boundlessness | 0.24 | 0.26 | −0.35 | 0.10 |
| Anxious ego dissolution | 0.04 | 0.07 | −0.10 | 0.32 |
| Visionary restructuralization | 0.12 | 0.15 | −0.59 | −0.16 |
| Auditory alterations | 0.02 | 0.12 | −0.18 | 0.08 |
| Reductions of vigilance | −0.01 | 0.13 | −0.10 | 0.38 |
| Experience of unity | 0.34 | 0.33 | −0.03 | 0.33 |
| Spiritual experience | −0.02 | 0.06 | −0.32 | −0.03 |
| Blissful state | 0.25 | 0.14 | −0.23 | 0.03 |
| Insightfulness | 0.24 | 0.20 | −0.37 | 0.12 |
| Disembodiment | −0.04 | 0.08 | −0.23 | 0.08 |
| Impaired control and cognition | −0.01 | 0.01 | −0.20 | 0.18 |
| Anxiety | 0.22 | 0.30 | 0.01 | 0.38 |
| Complex imagery | 0.06 | 0.14 | −0.28 | −0.04 |
| Elementary imagery | −0.13 | −0.03 | −0.53 | −0.15 |
| Audio-visual synesthesia | 0.23 | 0.26 | −0.01 | 0.00 |
| Changed meaning of percepts | −0.03 | −0.06 | −0.62 | −0.10 |
| Ego dissolution (item 71) | 0.40 | 0.51 | −0.27 | −0.14 |
| MEQ30 | ||||
| MEC30 total score | NA | −0.30 | 0.17 | |
| Mystical | NA | −0.25 | 0.13 | |
| Positive mood | NA | −0.08 | 0.21 | |
| Transcendence of time/space | NA | −0.23 | 0.10 | |
| Ineffability | NA | −0.49 | 0.13 | |
Values are Pearson correlation coefficients describing correlations, the peak concentrations of LSD predicted by the one-compartment model, and LSD-induced %5D-ASC and %MEQ30 scores. Bold values for P < 0.05C max maximal LSD plasma concentration predicted by the one-compartment pharmacokinetic model, AUC area under the LSD concentration-time curve predicted by the model