Table 2.
Geometric mean MIC, MIC range, MIC50 and MIC90 (μg/ml) of caspofungin, fluconazole and clotrimazole for 34 tested Candida strains
| Caspofungin (μg/ml) | C. albicans (30) | C. glabrata (3) | C. kefyr (1) | Total (34) | |||||
|---|---|---|---|---|---|---|---|---|---|
| 24h | 48h | 24h | 48h | 24h | 48h | 24h | 48h | ||
| R | 2 | 1 | 2 | - | - | - | - | 1 | 2 |
| 1 | 24 | 26 | - | - | - | 1 | 24 | 27 | |
| S | 0.5 | 3 | 2 | - | - | - | - | 3 | 2 |
| 0.25 | 2 | - | - | - | - | - | 2 | - | |
| 0.125 | - | - | 3 | 3 | 1 | - | 4 | 3 | |
| MIC50 | 1 | 1 | - | - | - | - | 1 | 1 | |
| MIC90 | 1 | 1 | - | - | - | - | 1 | 1 | |
| MICGM | 0.87 | 1 | - | - | - | - | 0.69 | 0.83 | |
| Fluconazole (μg/ml) | |||||||||
| 1 | 2 | 5 | - | - | - | - | 2 | 5 | |
| S | 0.5 | 7 | 6 | - | - | - | - | 7 | 6 |
| 0.25 | 21 | 19 | 3 | 3 | 1 | 1 | 25 | 23 | |
| 0.125 | - | - | - | - | - | - | - | - | |
| MIC50 | 0.25 | 0.25 | - | - | - | - | 0.25 | 0.25 | |
| MIC90 | 0.5 | 1 | - | - | - | - | 0.5 | 1 | |
| MICGM | 0.32 | 0.36 | - | - | - | - | 0.31 | 0.35 | |
| Clotrimazole (μg/ml) | |||||||||
| R | 1 | 1 | 3 | - | - | - | - | 1 | 3 |
| DD | 0.5 | 3 | 2 | - | - | - | - | 3 | 2 |
| S | 0.25 | 26 | 25 | 3 | 3 | 1 | 1 | 30 | 29 |
| 0.125 | - | - | - | - | - | - | - | - | |
| MIC50 | 0.25 | 0.25 | - | - | - | - | 0.25 | 0.25 | |
| MIC90 | 0.5 | 0.5 | - | - | - | - | 0.5 | 0.5 | |
| MICGM | 0.29 | 0.32 | - | - | - | - | 0.28 | 0.29 | |
MIC: Minimum Inhibitory Concentration; GM: Geometric Mean; R, Resistant; DD: Dose dependent; S, sensitive