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. 2017 May 6;9:31. doi: 10.1186/s13098-017-0228-y

Table 3.

Univariable regression analysis for urinary mRNA of podocyte-associated molecules

Parameter Variable R2 Coef β p
NPHS1-nephrin Podocytes 0.546 0.037 <0.0001
UACR 0.603 0.0003 <0.0001
Nephrin/creat 0.404 0.040 <0.0001
VEGF/creat 0.380 0.0003 <0.0001
Alpha1/creat 0.418 0.006 <0.0001
KIM-1/creat 0.482 0.0004 <0.0001
eGFR 0.575 −0.005 <0.0001
CystatinC 0.521 0.269 <0.0001
Urinary AGE 0.435 0.0004 <0.0001
NPHS2-podocin Podocytes 0.546 0.041 <0.0001
UACR 0.591 0.0003 <0.0001
Nephrin/creat 0.472 0.047 <0.0001
VEGF/creat 0.457 0.0003 <0.0001
Alpha1/creat 0.492 0.007 <0.0001
KIM-1/creat 0.553 0.0005 <0.0001
eGFR 0.607 −0.005 <0.0001
CystatinC 0.579 0.308 <0.0001
Urinary AGE 0.500 0.0005 <0.0001
Alpha actinin-4 Podocytes 0.538 0.045 <0.0001
UACR 0.540 0.0003 <0.0001
Nephrin/creat 0.399 0.048 <0.0001
VEGF/creat 0.383 0.0003 <0.0001
Alpha1/creat 0.403 0.007 <0.0001
KIM-1/creat 0.465 0.0005 <0.0001
eGFR 0.616 −0.006 <0.0001
CystatinC 0.539 0.330 <0.0001
Urinary AGE 0.427 0.0005 <0.0001
CD2-AP Podocytes 0.423 0.032 <0.0001
UACR 0.434 0.0002 <0.0001
Nephrin/creat 0.317 0.034 <0.0001
VEGF/creat 0.317 0.0002 <0.0001
Alpha1/creat 0.324 0.005 <0.0001
KIM-1/creat 0.378 0.0004 <0.0001
eGFR 0.474 −0.004 <0.0001
CystatinC 0.432 0.236 <0.0001
Urinary AGE 0.333 0.0003 <0.0001
ADAM10 Podocytes 0.494 0.040 <0.0001
UACR 0.491 0.0003 <0.0001
Nephrin/creat 0.378 0.043 <0.0001
VEGF/creat 0.366 0.0003 <0.0001
Alpha1/creat 0.388 0.006 <0.0001
KIM-1/creat 0.446 0.0005 <0.0001
eGFR 0.557 −0.005 <0.0001
CystatinC 0.500 0.293 <0.0001
Urinary AGE 0.400 0.0004 <0.0001
GLEPP-1 Podocytes 0.455 0.037 <0.0001
UACR 0.484 0.003 <0.0001
Nephrin/creat 0.387 0.042 <0.0001
VEGF/creat 0.391 0.0003 <0.0001
Alpha1/creat 0.409 0.006 <0.0001
KIM-1/creat 0.463 0.0005 <0.0001
eGFR 0.534 −0.005 <0.0001
CystatinC 0.499 0.282 <0.0001
Urinary AGE 0.414 0.0004 <0.0001
NfKB Podocytes 0.456 0.037 <0.0001
UACR 0.496 0.0003 <0.0001
Nephrin/creat 0.400 0.043 <0.0001
VEGF/creat 0.405 0.0003 <0.0001
Alpha1/creat 0.423 0.007 <0.0001
KIM-1/creat 0.577 0.0005 <0.0001
eGFR 0.536 −0.005 <0.0001
CystatinC 0.507 0.291 <0.0001
Urinary AGE 0.426 0.0004 <0.0001

UACR: urinary albumin:creatinine ratio; Alpha1/creat: urinary alpha1-microglobulin:creatinine ratio; KIM-1/creat: urinary kidney injury molecule-1:creatinine ratio; VEGF/creat: urinary vascular endothelial growth factor:creatinine ratio; Nephrin/creat: urinary nephrin:creatinine ratio; eGFR: estimated glomerular filtration rate; AGE: advanced glycation end-products; NPHS1-nephrin, NPHS2-podocin, CD2AP-CD2-associated protein, GLEPP 1-glomerular epithelial protein 1, NFkB-nuclear factor κB