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. 2017 May 6;9:31. doi: 10.1186/s13098-017-0228-y

Table 4.

Multivariable regression analysis for urinary mRNA of podocyte-associated molecules

Parameter Variable Coef β p 95% CI Prob > F R2
NPHS1 Constant 0.065 0.083 −0.008 to 0.140 <0.0001 0.808
Podocytes 0.021 <0.0001 0.015 to 0.027
UACR 0.0001 <0.0001 0.00006 to 0.0001
KIM-1/creat 0.0002 0.04 0.00001 to 0.0004
eGFR −0.0018 0.061 −0.0007 to −0.005
Nephrin/creat 0.0004 0.007 0.0002 to 0.001
NPHS2 Constant 0.029 0.449 −0.047 to 0.106 <0.0001 0.825
Podocytes 0.022 <0.0001 0.015 to 0.028
UACR 0.0001 <0.0001 0.00005 to 0.0001
KIM-1/creat 0.0002 0.013 0.00061 to 0.0005
eGFR −0.0009 0.004 −0.0015 to −0.0003
Nephrin/creat 0.0218 0.002 0.0341 to 0.5164
Alpha actinin-4 Constant 0.2411 0.085 −0.0341 to 0.5164 <0.0001 0.805
Podocytes 0.027 <0.0001 0.019 to 0.034
UACR 0.00009 0.01 0.00002 to 0.0001
eGFR −0.002 0.042 −0.0033 to −0.00007
CD2AP Constant 0.466 <0.0001 0.320 to 0.613 <0.0001 0.663
Podocytes 0.018 <0.0001 0.009 to 0.028
UACR 0.00008 0.04 4.00e−06 to 0.0001
eGFR −0.001 0.023 −0.0033 to −0.0002
KIM-1/creat 0.0008 0.007 0.0002 to 0.0014
VEGF 0.0004 0.005 0.0001 to 0.0007
ADAM10 Constant 0.055 0.265 −0.042 to 0.154 <0.0001 0.726
Podocytes 0.025 <0.0001 0.017 to 0.033
UACR 0.00008 0.032 7.57e-06 to 0.0001
eGFR −0.002 0.016 −0.0026 to −0.0004
Alpha-1 microglobulin 0.0074 <0.0001 0.0044 to 0.0105
GLEPP-1 Constant 0.435 <0.0001 0.287 to 0.583 <0.0001 0.720
Podocytes 0.02 <0.0001 0.01 to 0.029
UACR 0.0009 0.019 0.00001 to 0.0001
VEGF 0.0004 0.009 0.0001 to 0.0006
KIM-1/creat 0.0008 0.009 0.0002 to 0.001
eGFR −0.002 0.013 −0.003 to −0.0004
NFkB Constant 0.445 <0.0001 0.294 to 0.595 <0.0001 0.724
Podocytes 0.02 <0.0001 0.01 to 0.029
UACR 0.0001 0.011 0.00002 to 0.0001
VEGF 0.0003 0.010 0.00009 to 0.0007
KIM-1/creat 0.0007 0.019 0.0001 to 0.0014
eGFR −0.0019 0.018 −0.003 to −0.0003

UACR: urinary albumin:creatinine ratio; Alpha1/creat: urinary alpha1-microglobulin:creatinine ratio; KIM-1/creat: urinary kidney injury molecule-1:creatinine ratio; VEGF/creat: urinary vascular endothelial growth factor:creatinine ratio; Nephrin/creat: urinary nephrin:creatinine ratio; eGFR: estimated glomerular filtration rate; AGE advanced glycation end-products; NPHS1-nephrin, NPHS2-podocin, CD2AP-CD2-associated protein, GLEPP 1-glomerular epithelial protein 1, NFκB-nuclear factor κB